Connie and Steve Ballmer's donation will help endow scholarships, hire five researchers to study obesity and pay for a marketing campaign to promote the University of Oregon's academics.
The coffee company launched a mug fundraiser to raise money for OHSU's Knight Cancer Challenge.
Paul Allen's gift is believed to be the largest private donation to combat the deadly disease and provide support to health care workers in West Africa.
The University of Oregon plans to raise $2 billion, double the fundraising record set by a state university.
The 107-year-old nonprofit has nearly completed construction on a new intensive treatment group home and an expansion of its emergency psychiatric care facility.