This year's contest puts more emphasis on the companies' makeup in choosing winners.
The list includes Oregon Right to Life and timber baron Andrew Miller of Stimson Lumber.
Keen Inc., a footwear retailer, will make 300,000 shoes this year at its Portland shoe factory.
Electro Scientific Industries reported a 24% decline in sales last quarter and lost $8.3 million, 27 cents per share.
The manufacturer will lay off 20 full-time employees and about 50 temporary workers from its original Northwest plant.
Jive's Q2 sales totaled $43.4 million, up 23.2% from last year.
Nashville-based SESAC purchased the Portland company, which developed a platform for musicians to micro-license music for use on websites. Terms of the deal were not disclosed.