The high-profile bank will invest $50,000 in Greater Portland Inc., which aims to bolster the region's economy.
The Oregon bank wants to provide banking services to medical marijuana businesses in the state.
Pacific Crest Securities will join KeyBanc Capital Markets, the corporate and investment banking arm of Cleveland-based KeyCorp.
Oregon startups have raised $174 million to date, up from $162 million raised in 2013.
The Portland-based company was purchased by the Dallas-based community bank, Triumph Bancorp Inc.