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|Archives - May 2009|
|Friday, May 01, 2009|
From stronger teeth to sharper eyes to a rewired brain, Oregon innovators are finding ways to keep us living longer and better.
BY JON BELL
Who: Greta Binford, assistant professor of biology
Who: SAM Medical Products
Who: Chrissa Kioussi, assistant professor of pharmacology
Who: Bend Research
What: Drug delivery technology
You can cross your heart and hope to die, but thanks to scientists at Bend Research, you may never have to stick a needle in your eye — at least not to deliver drugs for glaucoma.
“As you can imagine, that’s not a lot of fun,” says Rod Ray, chief executive officer of the 34-year-old Bend medical company.
Among its other innovations, Bend Research is developing new technologies for administering drugs to the eyes, including drops that contain powerful medicine in nanoparticle form. Ray says researchers there have also been working on ways to make drugs more soluble and to target them to specific sites in the body. The latter would not only reduce the amount of drug needed, but would also help ensure that, say, cancer drugs would head straight for a tumor.
“That technology is a really important one for fighting cancer,” says Ray.
Bend Research, which developed the popular one-dose antibiotic Zmax, recently left a 14-year exclusive partnership with the pharmaceutical giant Pfizer, and is currently harvesting new relationships with biotech and drug companies around the world.
Ray says he sees the company continuing to make advances in the pharmaceutical realm and dabbling in the world of diagnostics. A possible next step: a new and better cholesterol test.
Who: Scott Frey, psychology professor
What: Brain adaptation research
Where: University of Oregon, Eugene
If Scott Frey is right about the human brain, we may be in for some monumental shifts in the treatment of everything from strokes to spinal cord damage.
Studying a handful of amputees who’ve been “cured” via hand transplants, Frey has learned that the brain is a mighty organizer. Not only does it reorganize itself after the limb is lost, but it then “re-reorganizes” itself when a new limb is attached. Feeling comes back and the brain begins processing signals from the new hand in the same region it did for the original hand.
“Our case presents the most compelling case that the brain can go back to the way it was,” Frey says.
The broader implication could theoretically mean that the brain would be able to rewire itself in, say, a paralyzed patient whose damaged spinal cord has been repaired by stem cells. Damage from strokes, concussive head injuries and diseases such as multiple sclerosis might also someday be abated with a better understanding of how the brain adapts.
Frey’s next wave of related research, funded by the Department of Defense, finds him recruiting arm and hand amputees to learn more about the brain’s role in phantom pain and the nearly 50% of upper limb amputees who reject prostheses.
“I would like to see us get a better understanding of these basic brain changes,” he says, “and the extent to which they can be reversed.”
Who: Neda Shamie, MD
What: Cataract and corneal surgery
Where: Legacy’s Devers Eye Institute, Portland
Oregon’s the right location for snowy mountains, microbrews and, apparently, afflictions of the eye.
“Oregon is a great place to be if you have an eye disease,” says Neda Shamie, a corneal and laser refractive surgeon at Legacy Good Samaritan Hospital’s Devers Eye Institute.
Shamie is one of Devers’ surgeons who specializes in some of the latest and greatest procedures out there. One example: advanced intraocular lens surgery for cataracts, where surgeons implant premium lenses that restore vision to near 20-20 and usually render reading glasses unnecessary.
But where Shamie and Devers really shine is in the realm of the cornea. Her colleague, Mark Terry, revolutionized cornea transplants 10 years ago with a technique that replaces only the damaged layer of the cornea, not the entire thickness as had been standard practice. Shamie herself has done more than 100 of those surgeries since joining Devers in 2006.
The institute is also one of the only facilities in Oregon to offer artificial cornea implanting, a new option for high-risk patients who’ve had multiple regular implants fail.
“There are books that can be written on what’s to come,” says Shamie.
Thursday, December 11, 2014
By MEGHAN NOLT
VIDEO: Revamping a Classic — an iconic eatery stays relevant in a changing marketplace.
Thursday, November 20, 2014
BY OB STAFF
Farmers, grocery stores and food processors cash in on kale.
Sunday, December 07, 2014
BY LINDA BAKER
On Friday, Uber switched on an app — and with one push of the button torpedoed Portland’s famed public process.
Saturday, December 13, 2014
Checking in with the managing director of Arnerich Massena.
Thursday, November 13, 2014
BY RYAN CARSON | OP-ED CONTRIBUTOR
How do we skill up our future technology workforce in a smart way to take advantage of these high-paying jobs? The answer shouldn’t focus only on helping people get a bachelor’s degree.
Tuesday, December 09, 2014
BY LINDA BAKER
On the eve of the Portland Ad Federation's Rosey Awards, Matt Anderson, CEO of Struck, talks about the transition from creative director to CEO, the Portland talent pool and whether data is the new black in the creative services sector.
Thursday, December 11, 2014
There’s a fascinating article in the December issue of the Harvard Business Review about a profound power shift taking place in business and society. It’s a long read, but the gist revolves around the tension between “old power” and “new power” as a driver of transformation. Here’s an excerpt:
The authors, Henry Timms and Jeremy Heimans, don’t necessarily favor one form of power over another but merely outline how power is transitioning, and how companies can take advantage of these changes to strengthen their positions in the marketplace.
Our Powerbook issue might be viewed as a case study in the new-power transition. This annual book of lists provides information on leading businesses, nonprofits and universities in the state. Most of the featured companies are entrenched power players now pursuing more flexible and less hierarchical approaches to doing business. Law firms, for example, are adopting new technologies and fee structures to make legal services more accessible and affordable.
This month we also take a look at a controversial new U.S. Securities and Exchange Commission rule requiring public companies to disclose the median pay of workers, as well as the ratio between CEO and median-worker pay.
Part of the 2010 Dodd-Frank financial reform law, the rule will compel public companies to be more open about employee compensation, with the assumption that greater transparency will improve corporate performance and, perhaps, help address one of the major challenges of our time: income inequality.
New power is not only about strategy and tactics, the Harvard Business Review authors say. “The ultimate questions are ethical. The big question is whether new power can genuinely serve the common good and confront society’s most intractable problems.”
That sounds like a call to arms. Or a New Year’s resolution. Old power or new, the goals are the same: to be a force for positive change in the world. Happy 2015!
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While the Bend City Council ultimately upheld the approval which enables OSU-Cascades to move forward with the 10 acre site, it did also thoughtfully consider the nature of its code requirements, resident concerns and OSU-Cascade’s efforts and suggestions and crafted conditions of approval to address potential impacts of the site in the area.