Home Back Issues December 2007 Next: OHSU's $5,000 mouse

Next: OHSU's $5,000 mouse

| Print |  Email
Archives - December 2007
Saturday, December 01, 2007


Mouse1207.jpg

It’s a tricky thing to talk up a mouse without getting cheesy. But this little guy, by all appearances a normal rodent, has a human liver inside of it, making it a real-life mighty mouse worth at least five grand. Markus Grompe of the Oregon Stem Cell Center at Oregon Health & Science University is breeding more of this star in hopes of revolutionizing the way drugs are tested. The mouse’s liver is infected with disease and then healthy human liver cells are transplanted into it; these human cells thrive until the liver is only 10% mouse. The new liver allows the mice to metabolize and excrete medications like a human. Pharmaceutical companies testing medication toxicity and searching for disease cures are interested because testing on this mouse is like testing on real human liver cells, which are hard to come by. Previous technology only allowed for an inconsequential number of human cells in mice, and a more recent Japanese version can’t control the liver disease or stop healthy mouse liver cells from regenerating. Those mice have shorter life spans and are difficult to breed, which makes Grompe optimistic that he’s developed a big seller. With the Japanese mice selling for $5,000 each, Grompe could be holding a small, furry fortune in his hands.   AMBER NOBE


Have an opinion? E-mail This e-mail address is being protected from spambots. You need JavaScript enabled to view it

 

More Articles

Shifting Ground

November/December 2014
Wednesday, October 22, 2014
BY JOE ROJAS-BURKE

Bans on genetically modified crops create uncertainty for farmers.


Read more...

I Know How You Feel

November/December 2014
Wednesday, October 22, 2014
BY JESSICA RIDGWAY

Most smartphones come equipped with speech recognition systems like Siri or Cortana that are capable of understanding the human voice and putting words into actions. But what if smartphones could do more? What if smartphones could register feeling?


Read more...

Constant Contact

October 2014
Thursday, September 25, 2014
BY AMY MILSHTEIN

To prevent burnout, companies are banning email and after-hours communications. But is the 24-hour workday here to stay?


Read more...

Political Clout

November/December 2014
Wednesday, October 22, 2014
BY KIM MOORE

Businesses spend billions of dollars each year trying to influence political decision makers by piling money into campaigns.


Read more...

Podcast: Turn Things Around with David Marquet

Contributed Blogs
Friday, October 17, 2014
davidmarquet thumbBY TOM COX | OB BLOGGER

How can you move from a command-and-control leadership model to one of true empowerment and accountability? David Marquet did, and he took notes along the way.


Read more...

Kill the Meeting

November/December 2014
Wednesday, October 22, 2014
BY AMY MILSHTEIN

Meetings get a bad rap. A few local companies make them count.


Read more...

OB Poll: Wineries and groceries

News
Friday, October 24, 2014

24-winethumbA majority of respondents agreed: Local vineyards should remain Oregon-owned and quality is the most important factor when determining where to eat or buy groceries.


Read more...
Oregon Business magazinetitle-sponsored-links-02
SPONSORED LINKS