Next: OHSU's $5,000 mouse

| Print |  Email
Archives - December 2007
Saturday, December 01, 2007


Mouse1207.jpg

It’s a tricky thing to talk up a mouse without getting cheesy. But this little guy, by all appearances a normal rodent, has a human liver inside of it, making it a real-life mighty mouse worth at least five grand. Markus Grompe of the Oregon Stem Cell Center at Oregon Health & Science University is breeding more of this star in hopes of revolutionizing the way drugs are tested. The mouse’s liver is infected with disease and then healthy human liver cells are transplanted into it; these human cells thrive until the liver is only 10% mouse. The new liver allows the mice to metabolize and excrete medications like a human. Pharmaceutical companies testing medication toxicity and searching for disease cures are interested because testing on this mouse is like testing on real human liver cells, which are hard to come by. Previous technology only allowed for an inconsequential number of human cells in mice, and a more recent Japanese version can’t control the liver disease or stop healthy mouse liver cells from regenerating. Those mice have shorter life spans and are difficult to breed, which makes Grompe optimistic that he’s developed a big seller. With the Japanese mice selling for $5,000 each, Grompe could be holding a small, furry fortune in his hands.   AMBER NOBE


Have an opinion? E-mail This e-mail address is being protected from spambots. You need JavaScript enabled to view it

 

More Articles

Store Bought

July/August 2015
Friday, July 10, 2015
BY LINDA BAKER

Market of Choice is on a tear. In 2012 the 35-year-old Eugene-based grocery chain opened a central kitchen/distribution center in its hometown. The market opened a third Portland store in the Cedar Mill neighborhood this year; a Bend outpost broke ground in March. A fourth Portland location is slated for the inner southeast “LOCA” development, a mixed-use project featuring condos and retail. Revenues in 2014 were $175 million, a double-digit increase over 2013. CEO Rick Wright discusses growth, market trends and how he keeps new “foodie” grocery clerks happy.


Read more...

Reader Input: Energy Overload

June 2015
Wednesday, July 15, 2015

We asked readers to weigh in on the fossil fuel-green energy equation.


Read more...

Balancing Act

July/August 2015
Friday, July 10, 2015
BY DAN COOK

The Affordable Care Act has triggered a rush on health care plan redesign, a process fraught with hidden costs and consequences.


Read more...

Fueling Up for the Climb

July/August 2015
Friday, July 10, 2015
BY GREGG MORRIS

Rita Hansen aims to scale natural gas vehicle innovation.


Read more...

Wildcards

Guest Blog
Tuesday, July 28, 2015
072815fergusonthumbBY JASON NORRIS

Uncertainty in Greece and China, along with potential interest rate hikes mean investors are looking at the market and nervously questioning where they should be invested.


Read more...

Reader Input: School Choice

September 2015
Thursday, August 20, 2015

Which of the following would be most effective in reducing the cost of operating a public university in Oregon?


Read more...

Baby. Boom!

September 2015
Wednesday, August 26, 2015
BY LINDA BAKER

A new co-working model disrupts office sharing, child care and work-life balance as we know it.


Read more...
Oregon Business magazinetitle-sponsored-links-02
SPONSORED LINKS