Home Back Issues November/December 2013 OHSU researchers work on AIDS vaccine

OHSU researchers work on AIDS vaccine

| Print |  Email
Articles - November/December 2013
Monday, October 28, 2013

BY LINDA BAKER

1113 NextTo develop a vaccine, researchers typically identify the disease agent, weaken or kill it, then set it loose in the body. The immune system destroys the weakened virus, leaving the vaccinated individual with a host of immune cells to ward off future infection. Alas, that time-honored strategy doesn’t work with HIV; you can’t weaken the virus enough so it is still safe to dole out in vaccine form. HIV is also especially tricky to clear completely from the body. To get around these challenges, Louis Picker, associate director of the OHSU Vaccine and Gene Therapy Institute, created an experimental AIDS vaccine from cytomegalovirus, a virus that is just as persistent as HIV but doesn’t cause disease. In tests on 16 monkeys, the vaccine eliminated an aggressive form of HIV in half of them — the first ever to demonstrate that kind of success. “The standard vaccine generates a big [immune] response, but that response ultimately goes away,” Picker says. “Ours keeps the T-cells armed and ready all the time.” His team is now working to translate the vaccine into a form suitable for humans — and figure out why some of the monkeys were not protected. There are about 50 million HIV infections worldwide; none have been eradicated. With the new vaccine, Picker says, the odds are better. “The score is host 50, virus 50.”

 

More Articles

Woman of Steel

November/December 2014
Wednesday, October 22, 2014
BY LINDA BAKER

Tamara Lundgren tackles the challenges—without getting trampled.


Read more...

The short list: 5 hot coffee shops for entrepreneurs

Contributed Blogs
Friday, November 14, 2014

CupojoeBY JESSICA RIDGWAY

Oregon entrepreneurs reveal their favorite caffeine hangouts.


Read more...

100 Best Nonprofits to Work for in Oregon [VIDEO]

News
Thursday, October 02, 2014

Screen shot 2014-10-02 at 11.17.21 AMMore than 5,500 employees from 180 organizations throughout the state participated in the 100 Best Nonprofits to Work for in Oregon project.


Read more...

Water World

November/December 2014
Wednesday, October 22, 2014
BY KIM MOORE

Fred Ziari aims to feed the global population.


Read more...

Books Rule

October 2014
Thursday, September 25, 2014
BY JON BELL

Powell's stays relevant in the digital age.


Read more...

Election Season

November/December 2014
Wednesday, October 22, 2014

We didn’t intend this issue to have an election season theme. But politics has a way of seeping into the cracks and fissures.


Read more...

Two Sides of the Coin

Contributed Blogs
Friday, September 26, 2014
0926 iphone6-thumbBY JASON NORRIS | GUEST BLOGGER

This post focuses on the recent release of the new Apple iPhone as well as Alibaba's IPO, the largest U.S. IPO in history.


Read more...
Oregon Business magazinetitle-sponsored-links-02
SPONSORED LINKS