OHSU researchers work on AIDS vaccine

| Print |  Email
Articles - November/December 2013
Monday, October 28, 2013

BY LINDA BAKER

1113 NextTo develop a vaccine, researchers typically identify the disease agent, weaken or kill it, then set it loose in the body. The immune system destroys the weakened virus, leaving the vaccinated individual with a host of immune cells to ward off future infection. Alas, that time-honored strategy doesn’t work with HIV; you can’t weaken the virus enough so it is still safe to dole out in vaccine form. HIV is also especially tricky to clear completely from the body. To get around these challenges, Louis Picker, associate director of the OHSU Vaccine and Gene Therapy Institute, created an experimental AIDS vaccine from cytomegalovirus, a virus that is just as persistent as HIV but doesn’t cause disease. In tests on 16 monkeys, the vaccine eliminated an aggressive form of HIV in half of them — the first ever to demonstrate that kind of success. “The standard vaccine generates a big [immune] response, but that response ultimately goes away,” Picker says. “Ours keeps the T-cells armed and ready all the time.” His team is now working to translate the vaccine into a form suitable for humans — and figure out why some of the monkeys were not protected. There are about 50 million HIV infections worldwide; none have been eradicated. With the new vaccine, Picker says, the odds are better. “The score is host 50, virus 50.”

 

More Articles

Old school: Paulsen's Pharmacy maintains old fashion ethos

The Latest
Thursday, December 18, 2014
121914-pharmacy-thumbBY MEGHAN NOLT

VIDEO: Under the radar — complete with a soda counter, the traditional Paulsen's Pharmacy looks to compete with big box retailers.


Read more...

See How They Run

January-Powerbook 2015
Friday, December 12, 2014
BY LINDA BAKER

Studying ground-running birds, a group that ranks among nature's speediest and most agile bipedal runners, to build a faster robot.


Read more...

The clean fuels opportunity

News
Monday, November 10, 2014
111014-dirtyfuel-thumbBY KIM MOORE | OB RESEARCH EDITOR

A market for low-carbon transportation fuels has a chance to flourish in Oregon if regulators adopt the second phase of the state’s Clean Fuels Program.


Read more...

Woman of Steel

November/December 2014
Wednesday, October 22, 2014
BY LINDA BAKER

Tamara Lundgren tackles the challenges—without getting trampled.


Read more...

Free Falling

Contributed Blogs
Thursday, December 18, 2014
121714-oilprice-thumbBY JASON NORRIS | OB CONTRIBUTOR

The implosion of the energy complex: The best thing for low oil prices is low oil prices.


Read more...

Shuffling the Deck

November/December 2014
Wednesday, October 22, 2014
BY JON BELL

Oregon tribes still bet on casinos.


Read more...

Corner Office: Marv LaPorte

January-Powerbook 2015
Saturday, December 13, 2014

The president of LaPorte & Associates lets us in on his day-to-day life.


Read more...
Oregon Business magazinetitle-sponsored-links-02
SPONSORED LINKS