OHSU researchers work on AIDS vaccine

| Print |  Email
Articles - November/December 2013
Monday, October 28, 2013

BY LINDA BAKER

1113 NextTo develop a vaccine, researchers typically identify the disease agent, weaken or kill it, then set it loose in the body. The immune system destroys the weakened virus, leaving the vaccinated individual with a host of immune cells to ward off future infection. Alas, that time-honored strategy doesn’t work with HIV; you can’t weaken the virus enough so it is still safe to dole out in vaccine form. HIV is also especially tricky to clear completely from the body. To get around these challenges, Louis Picker, associate director of the OHSU Vaccine and Gene Therapy Institute, created an experimental AIDS vaccine from cytomegalovirus, a virus that is just as persistent as HIV but doesn’t cause disease. In tests on 16 monkeys, the vaccine eliminated an aggressive form of HIV in half of them — the first ever to demonstrate that kind of success. “The standard vaccine generates a big [immune] response, but that response ultimately goes away,” Picker says. “Ours keeps the T-cells armed and ready all the time.” His team is now working to translate the vaccine into a form suitable for humans — and figure out why some of the monkeys were not protected. There are about 50 million HIV infections worldwide; none have been eradicated. With the new vaccine, Picker says, the odds are better. “The score is host 50, virus 50.”

 

More Articles

Help Wanted: Poached Jobs aids restaurateurs

March 2015
Friday, February 20, 2015
BY JACOB PALMER | OB DIGITAL NEWS EDITOR

“We thought there was room for something new.”


Read more...

5 companies react to lower fuel prices

The Latest
Thursday, January 15, 2015
thumb-shutterstock 233787049BY JACOB PALMER | OB DIGITAL NEWS EDITOR

Consumers love the savings they get from low oil prices, but how has business been affected?


Read more...

The city as startup

Guest Blog
Wednesday, January 14, 2015
011415 citystartup-thumbBY NISHANT BHAJARIA | OP-ED CONTRIBUTOR

Startups in the growth phase are associated with a fresh infusion of capital — human and financial — a curiosity factor and products to disrupt the market and drive demand. Portland’s economy gives off the same aroma.


Read more...

Live, Work, Play: Amen Teter

February 2015
Tuesday, January 27, 2015
BY JACOB PALMER

Catching up with Amen Teter, Portland-based global director of action sports for Octagon Olympics & Action sports talent agency.


Read more...

Ski traffic

Linda Baker
Tuesday, January 20, 2015
0121-skiway-thumbBY LINDA BAKER | OB EDITOR

A place-based multimodal transportation plan for Mt. Hood is long overdue.


Read more...

Convention Wisdom

February 2015
Monday, January 26, 2015
BY KIM MOORE

After more than a decade of wrangling, construction on a convention center hotel in Portland is slated to start this summer. But debate over project financing continues.


Read more...

All Rise

March 2015
Friday, February 20, 2015
BY AMY MILSHTEIN | OB CONTRIBUTOR

Don’t just sit there. For a healthy workplace, move up and down — and all around.


Read more...
Oregon Business magazinetitle-sponsored-links-02
SPONSORED LINKS