Home Back Issues July/August 2013 Next: cancer treatment

Next: cancer treatment

| Print |  Email
Articles - July/August 2013
Monday, July 08, 2013

BY LINDA BAKER

0713 NextIn another win for the revolution that is DNA sequencing, researchers at Oregon Health & Science University have identified the genetic mutation that causes two rare forms of leukemia. The discovery was especially heartening since it turns out existing FDA-approved therapies can be used to treat both diseases. The research involved a two-pronged, out-of-the-box approach: DNA sequencing of specimens from patients to identify gene mutations, along with the testing of 140 drugs on the patients’ cancerous tissues. Researchers typically test drug therapies on “immortalized cell lines,” says Jeff Tyner, an assistant professor with the OHSU Knight Cancer Institute and Cell & Developmental Biology department. “We’ve developed the technology to do it directly on the tumor, which is more relevant to the actual patients.” The simultaneous drug-testing/gene-sequencing approach allowed scientists to identify two therapies that were effective on the mutation that causes chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) in some patients. The next step is to embark on a clinical trial to treat more people suffering from the diseases. So far, the few patients who have received treatment “have had really dramatic and durable responses,” says Tyner. “It looks very exciting.” 

 

More Articles

Water World

November/December 2014
Wednesday, October 22, 2014
BY KIM MOORE

Fred Ziari aims to feed the global population.


Read more...

Kill the Meeting

November/December 2014
Wednesday, October 22, 2014
BY AMY MILSHTEIN

Meetings get a bad rap. A few local companies make them count.


Read more...

What I'm Reading

November/December 2014
Wednesday, October 22, 2014

Peter Lizotte at ACME Business Solutions and Roger Busse at Pacific Continental Bank share their favorite reads.


Read more...

The Bookseller

November/December 2014
Wednesday, October 22, 2014
BY AMY MILSHTEIN

Everyone knows college is expensive, but a look at the numbers brings that into sharp — and painful — focus.


Read more...

A Complex Portrait: Immigration, Jobs and the Economy

November/December 2014
Wednesday, October 22, 2014
BY JOE ROJAS-BURKE & KIM MOORE

Oregon Business reports on the visa squeeze, the skills gap and foreign-born residents who are revitalizing rural Oregon.


Read more...

Podcast: Turn Things Around with David Marquet

Contributed Blogs
Friday, October 17, 2014
davidmarquet thumbBY TOM COX | OB BLOGGER

How can you move from a command-and-control leadership model to one of true empowerment and accountability? David Marquet did, and he took notes along the way.


Read more...

Semiconductor purgatory

News
Monday, October 06, 2014
roundup-logo-thumb-14BY LINDA BAKER | OB EDITOR

Intel's manufacturing way station; Merkley's attack dog; Diamond Foods gets into the innovation business.


Read more...
Oregon Business magazinetitle-sponsored-links-02
SPONSORED LINKS