Sponsored by Oregon Business

Next: cancer treatment

| Print |  Email
Articles - July/August 2013
Monday, July 08, 2013

BY LINDA BAKER

0713 NextIn another win for the revolution that is DNA sequencing, researchers at Oregon Health & Science University have identified the genetic mutation that causes two rare forms of leukemia. The discovery was especially heartening since it turns out existing FDA-approved therapies can be used to treat both diseases. The research involved a two-pronged, out-of-the-box approach: DNA sequencing of specimens from patients to identify gene mutations, along with the testing of 140 drugs on the patients’ cancerous tissues. Researchers typically test drug therapies on “immortalized cell lines,” says Jeff Tyner, an assistant professor with the OHSU Knight Cancer Institute and Cell & Developmental Biology department. “We’ve developed the technology to do it directly on the tumor, which is more relevant to the actual patients.” The simultaneous drug-testing/gene-sequencing approach allowed scientists to identify two therapies that were effective on the mutation that causes chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) in some patients. The next step is to embark on a clinical trial to treat more people suffering from the diseases. So far, the few patients who have received treatment “have had really dramatic and durable responses,” says Tyner. “It looks very exciting.” 

 

More Articles

Everything old is new again: How the EEOC is reinventing itself

Contributed Blogs
Tuesday, February 17, 2015
BY TAMSEN LEACHMAN | OB GUEST CONTRIBUTOR

It is important to understand the EEOC’s priorities, and ensure that your leadership understands the shifting expectations of regulators and the heightened standards to which you (and they) may be held.


Read more...

4 highlights of the MLS labor deal

The Latest
Wednesday, March 04, 2015
timbersthumbBY JACOB PALMER | OB DIGITAL NEWS EDITOR

On Wednesday night, a couple days ahead of the 2015 season kickoff, Major League Soccer and the Players Union reached an agreement.


Read more...

Meeting Facilities Perspective

March 2015
Tuesday, February 24, 2015
BY KIM MOORE | OB RESEARCH EDITOR

A conversation with Donna Earley, director of sales and marketing for the Salem Convention Center.


Read more...

How Oregon will survive the loss of Hanjin

March 2015
Friday, February 20, 2015
BY JOE CORTRIGHT | OB CONTRIBUTOR

"Shipping containers to Portland is like waiting for a bus that travels once a day."


Read more...

Nuclear fingerprints

March 2015
Tuesday, February 24, 2015
BY LINDA BAKER | OB EDITOR

At Oregon State University, a 21st century version of the bad dream — nuclear terrorism — is alive and well. This winter, the Department of Nuclear Physics and Radiation Health Physics created a new interdisciplinary graduate emphasis in nuclear forensics, a Sherlock Holmes-sounding program that aims to identify how and where confiscated nuclear and radiological materials were created.


Read more...

Power Players

April 2015
Friday, March 27, 2015
BY ROBERT MULLIN

A new energy-sharing agreement sparks concerns about independence and collaboration in the region's utility industry.


Read more...

Opening soon: 3 of the coolest new breweries in Oregon

The Latest
Thursday, March 19, 2015
brewthumbBY JACOB PALMER | DIGITAL NEWS EDITOR

There are 278 companies licensed to operate as brewery, according to the Oregon Liquor Control Commission. Here are three new beer-making hubs slated to open soon.


Read more...
Oregon Business magazinetitle-sponsored-links-02
SPONSORED LINKS