Home Back Issues July/August 2013 Next: cancer treatment

Next: cancer treatment

| Print |  Email
Articles - July/August 2013
Monday, July 08, 2013

BY LINDA BAKER

0713 NextIn another win for the revolution that is DNA sequencing, researchers at Oregon Health & Science University have identified the genetic mutation that causes two rare forms of leukemia. The discovery was especially heartening since it turns out existing FDA-approved therapies can be used to treat both diseases. The research involved a two-pronged, out-of-the-box approach: DNA sequencing of specimens from patients to identify gene mutations, along with the testing of 140 drugs on the patients’ cancerous tissues. Researchers typically test drug therapies on “immortalized cell lines,” says Jeff Tyner, an assistant professor with the OHSU Knight Cancer Institute and Cell & Developmental Biology department. “We’ve developed the technology to do it directly on the tumor, which is more relevant to the actual patients.” The simultaneous drug-testing/gene-sequencing approach allowed scientists to identify two therapies that were effective on the mutation that causes chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) in some patients. The next step is to embark on a clinical trial to treat more people suffering from the diseases. So far, the few patients who have received treatment “have had really dramatic and durable responses,” says Tyner. “It looks very exciting.” 

 

More Articles

Election Season

November/December 2014
Wednesday, October 22, 2014

We didn’t intend this issue to have an election season theme. But politics has a way of seeping into the cracks and fissures.


Read more...

Reimagining education to solve Oregon's student debt and underemployment problems

News
Thursday, November 13, 2014
carsonstudentdept-thumbBY RYAN CARSON | OP-ED CONTRIBUTOR

How do we skill up our future technology workforce in a smart way to take advantage of these high-paying jobs? The answer shouldn’t focus only on helping people get a bachelor’s degree.


Read more...

October surprise

News
Sunday, October 12, 2014
roundup-logo-thumb-14BY LINDA BAKER

Cylvia Hayes, tabloid vs. watchdog journalism and the looming threat of a Cascadia earthquake.


Read more...

Podcast: Turn Things Around with David Marquet

Contributed Blogs
Friday, October 17, 2014
davidmarquet thumbBY TOM COX | OB BLOGGER

How can you move from a command-and-control leadership model to one of true empowerment and accountability? David Marquet did, and he took notes along the way.


Read more...

Political Clout

November/December 2014
Wednesday, October 22, 2014
BY KIM MOORE

Businesses spend billions of dollars each year trying to influence political decision makers by piling money into campaigns.


Read more...

The 100 Best Companies survey is open

News
Friday, October 24, 2014

100-best-logo-2015 500pxw-1How does your workplace stack up against competitors? How can you improve workplace practices to help recruit and retain employees? Find out by taking our 100 Best Companies to Work for in Oregon survey!


Read more...

Measure 91: What Oregon Businesses Need to Know

Contributed Blogs
Wednesday, October 15, 2014
91 thumbBY DIANE BUISMAN

Some common misconceptions employers have about marijuana.


Read more...
Oregon Business magazinetitle-sponsored-links-02
SPONSORED LINKS