Home Back Issues July/August 2013 Next: cancer treatment

Next: cancer treatment

| Print |  Email
Articles - July/August 2013
Monday, July 08, 2013

BY LINDA BAKER

0713 NextIn another win for the revolution that is DNA sequencing, researchers at Oregon Health & Science University have identified the genetic mutation that causes two rare forms of leukemia. The discovery was especially heartening since it turns out existing FDA-approved therapies can be used to treat both diseases. The research involved a two-pronged, out-of-the-box approach: DNA sequencing of specimens from patients to identify gene mutations, along with the testing of 140 drugs on the patients’ cancerous tissues. Researchers typically test drug therapies on “immortalized cell lines,” says Jeff Tyner, an assistant professor with the OHSU Knight Cancer Institute and Cell & Developmental Biology department. “We’ve developed the technology to do it directly on the tumor, which is more relevant to the actual patients.” The simultaneous drug-testing/gene-sequencing approach allowed scientists to identify two therapies that were effective on the mutation that causes chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) in some patients. The next step is to embark on a clinical trial to treat more people suffering from the diseases. So far, the few patients who have received treatment “have had really dramatic and durable responses,” says Tyner. “It looks very exciting.” 

 

More Articles

Knight Vision

October 2014
Thursday, September 25, 2014
BY VIVIAN MCINERNY

Travis Knight wants to release a movie a year. Can he pull it off?


Read more...

Podcast: Interview with Pete Friedes

Contributed Blogs
Wednesday, August 27, 2014

082714-thumb friedesbookTom Cox interviews Pete Friedes, author of "The 2R Manager," about becoming a Best Boss.


Read more...

Fork & Bottle

October 2014
Thursday, September 25, 2014

National media can’t get enough of Oregon’s pinot noir, artisan-food purveyors and lively, independent film scene.


Read more...

How to add positivity to your team

Contributed Blogs
Friday, September 12, 2014
happy-seo-orlando-clientsBY TOM COX | OB BLOGGER

I often talk about what leaders can do. What about followers? If you’re a team member and you’d like to add positivity to your team, what might you do?


Read more...

Semiconductor purgatory

News
Monday, October 06, 2014
roundup-logo-thumb-14BY LINDA BAKER | OB EDITOR

Intel's manufacturing way station; Merkley's attack dog; Diamond Foods gets into the innovation business.


Read more...

Powerlist: Colleges and Universities

September 2014
Wednesday, August 27, 2014
BY KIM MOORE

A conversation about higher education with the presidents of the University of Oregon and Clackamas Community College, followed by September's powerlist.


Read more...

Gender Code

September 2014
Tuesday, August 26, 2014
BY COURTNEY SHERWOOD

Janice Levenhagen-Seeley reprograms tech.


Read more...
Oregon Business magazinetitle-sponsored-links-02
SPONSORED LINKS