Sponsored by Lane Powell

Next: cancer treatment

| Print |  Email
Articles - July/August 2013
Monday, July 08, 2013

BY LINDA BAKER

0713 NextIn another win for the revolution that is DNA sequencing, researchers at Oregon Health & Science University have identified the genetic mutation that causes two rare forms of leukemia. The discovery was especially heartening since it turns out existing FDA-approved therapies can be used to treat both diseases. The research involved a two-pronged, out-of-the-box approach: DNA sequencing of specimens from patients to identify gene mutations, along with the testing of 140 drugs on the patients’ cancerous tissues. Researchers typically test drug therapies on “immortalized cell lines,” says Jeff Tyner, an assistant professor with the OHSU Knight Cancer Institute and Cell & Developmental Biology department. “We’ve developed the technology to do it directly on the tumor, which is more relevant to the actual patients.” The simultaneous drug-testing/gene-sequencing approach allowed scientists to identify two therapies that were effective on the mutation that causes chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) in some patients. The next step is to embark on a clinical trial to treat more people suffering from the diseases. So far, the few patients who have received treatment “have had really dramatic and durable responses,” says Tyner. “It looks very exciting.” 

 

More Articles

Raising the Stakes

February 2015
Monday, January 26, 2015
BY LINDA BAKER

The 2014 Bend Venture Conference set a record for the most cash, investments and prizes awarded at an angel conference in the Pacific Northwest. Investments in the six winning companies exceeded $1 million. The 11th annual conference was hosted by Economic Development of Central Oregon.


Read more...

100 Best: The Power of the Worker

March 2015
Wednesday, February 25, 2015
BY KIM MOORE | OB RESEARCH EDITOR
AND AMY MILSHTEIN | OB CONTRIBUTOR

Technology is empowering people like never before and transforming how employees interact in the workplace. How can companies attract and keep staff engaged in this rapidly changing world?


Read more...

Light Moves

February 2015
Monday, January 26, 2015
BY JACOB PALMER

Fittingly, Light at Play — a business whose sole purpose is to create mesmerizing ambience — was conceived at Burning Man.


Read more...

Will Medford Ever Be Cool?

February 2015
Friday, January 23, 2015
BY DAN COOK | PHOTOS BY JASON E. KAPLAN

A real-estate developer and a Lithia Motors executive aim to revamp the city's forlorn downtown.


Read more...

VIDEO: The 2015 100 Best Companies to Work For in Oregon

The Latest
Friday, February 27, 2015

videothumbVIDEO: 2015 100 Best Companies to work for in Oregon


Read more...

The Carbon Calculus

February 2015
Friday, January 23, 2015
BY KIM MOORE | OB RESEARCH EDITOR

Carbon pricing is gaining momentum in Oregon, sparking concern for energy-intensive businesses — but also opportunity to expand a homespun green economy.


Read more...

Umbrella Revolution

March 2015
Monday, February 23, 2015

Yeah, we know: Oregonians are way too cool for umbrellas. But today’s stylish, high-tech models will soften the resistance of the most rain hardened.


Read more...
Oregon Business magazinetitle-sponsored-links-02
SPONSORED LINKS