Home Back Issues March 2013 Next: ditch the itch

Next: ditch the itch

| Print |  Email
Articles - March 2013
Monday, February 25, 2013

 

BY LINDA BAKER

0313 NextItchy and inflamed skin is the bane of existence for people who suffer from atopic dermatitis, a type of eczema most common in infancy that also affects millions of adults around the world. Now scientists at Oregon State University have discovered an underlying genetic cause for the condition, a discovery that may lead to more effective therapies. The culprit is “Ctip2,” a protein and “master” regulator that controls the production of lipids, the fats that help keep the skin healthy. The regulator also suppresses a protein manufactured by skin cells that can cause irritation. In animal studies, researchers found that malfunctioning Ctip2 can produce eczema either by reducing the lipids in the skin or by allowing the protein that triggers inflammation to form. To alleviate both problems, scientists are working on topical compounds that would restore fat levels and possibly increase the expression of Ctip2, said Arup Indra, an associate professor in the OSU College of Pharmacy. The development of such treatments could eventually lead to personalized gene therapies, says Indra. “Our understanding of genomics is improving day by day, even hourly,” Indra says. “The challenge is using that understanding to develop therapies that are effective.”

 

More Articles

Community colleges and sustainability

Contributed Blogs
Thursday, July 31, 2014
sustainabilityBY MARY SPILDE | OB GUEST CONTRIBUTOR

Faced with the aftermath of the “great recession,” increasing concern about the environment and dwindling family wage jobs, we have some very important choices to make about our future.


Read more...

A Taste of Heaven

September 2014
Tuesday, August 26, 2014
BY VIVIAN MCINERNY

Craft beer comes to Mount Angel.


Read more...

Register for 100 Best Companies survey

News
Wednesday, August 20, 2014
OBM-100-best-logo-2015 150pxwBy Kim Moore | OB Editor

The 2015 survey launched this week. It is open to for-profit private and public companies that have at least 15 full- or part-time employees in Oregon.


Read more...

College Hacker

September 2014
Wednesday, August 27, 2014
BY KLINT FINLEY

Treehouse CEO Ryan Carson builds a 21st-century trade school.


Read more...

Portland rises

News
Monday, August 18, 2014

IMG 2551Portland is in the middle of another construction boom, with residential and office projects springing up downtown, in the Pearl and Old Town. OB Web Editor Jessica Ridgway documents the new wave.


Read more...

Private liberal arts education: superior outcomes, competitive price

Contributed Blogs
Tuesday, August 26, 2014
0826 thumb collegemoneyBY DEBRA RINGOLD | OP-ED CONTRIBUTOR

Why has six years become an acceptable investment in public undergraduate education that over-promises and underperforms?


Read more...

Report Card

September 2014
Tuesday, August 26, 2014

Strong public schools shore up the economy, survey respondents say. But local schools demonstrate lackluster performance.


Read more...
Oregon Business magazinetitle-sponsored-links-02
SPONSORED LINKS