Home Back Issues March 2013 Next: ditch the itch

Next: ditch the itch

| Print |  Email
Articles - March 2013
Monday, February 25, 2013

 

BY LINDA BAKER

0313 NextItchy and inflamed skin is the bane of existence for people who suffer from atopic dermatitis, a type of eczema most common in infancy that also affects millions of adults around the world. Now scientists at Oregon State University have discovered an underlying genetic cause for the condition, a discovery that may lead to more effective therapies. The culprit is “Ctip2,” a protein and “master” regulator that controls the production of lipids, the fats that help keep the skin healthy. The regulator also suppresses a protein manufactured by skin cells that can cause irritation. In animal studies, researchers found that malfunctioning Ctip2 can produce eczema either by reducing the lipids in the skin or by allowing the protein that triggers inflammation to form. To alleviate both problems, scientists are working on topical compounds that would restore fat levels and possibly increase the expression of Ctip2, said Arup Indra, an associate professor in the OSU College of Pharmacy. The development of such treatments could eventually lead to personalized gene therapies, says Indra. “Our understanding of genomics is improving day by day, even hourly,” Indra says. “The challenge is using that understanding to develop therapies that are effective.”

 

More Articles

Gone Girl

News
Monday, September 29, 2014
roundup-logo-thumb-14BY LINDA BAKER | OB EDITOR

Wehby disappears, Kitzhaber fails to disclose and Seattle gets bike share before Portland.


Read more...

Kill the Meeting

November/December 2014
Wednesday, October 22, 2014
BY AMY MILSHTEIN

Meetings get a bad rap. A few local companies make them count.


Read more...

Knight Vision

October 2014
Thursday, September 25, 2014
BY VIVIAN MCINERNY

Travis Knight wants to release a movie a year. Can he pull it off?


Read more...

Woman of Steel

November/December 2014
Wednesday, October 22, 2014
BY LINDA BAKER

Tamara Lundgren tackles the challenges—without getting trampled.


Read more...

100 Best Nonprofits to Work for in Oregon [VIDEO]

News
Thursday, October 02, 2014

Screen shot 2014-10-02 at 11.17.21 AMMore than 5,500 employees from 180 organizations throughout the state participated in the 100 Best Nonprofits to Work for in Oregon project.


Read more...

Election Season

November/December 2014
Wednesday, October 22, 2014

We didn’t intend this issue to have an election season theme. But politics has a way of seeping into the cracks and fissures.


Read more...

Revenge Forestry

November/December 2014
Tuesday, October 14, 2014
BY JONATHAN FROCHTZWAJG

A flare-up in the Elliott Forest raises questions about détente in Oregon’s timber wars.


Read more...
Oregon Business magazinetitle-sponsored-links-02
SPONSORED LINKS