Home Back Issues March 2013 Next: ditch the itch

Next: ditch the itch

| Print |  Email
Articles - March 2013
Monday, February 25, 2013

 

BY LINDA BAKER

0313 NextItchy and inflamed skin is the bane of existence for people who suffer from atopic dermatitis, a type of eczema most common in infancy that also affects millions of adults around the world. Now scientists at Oregon State University have discovered an underlying genetic cause for the condition, a discovery that may lead to more effective therapies. The culprit is “Ctip2,” a protein and “master” regulator that controls the production of lipids, the fats that help keep the skin healthy. The regulator also suppresses a protein manufactured by skin cells that can cause irritation. In animal studies, researchers found that malfunctioning Ctip2 can produce eczema either by reducing the lipids in the skin or by allowing the protein that triggers inflammation to form. To alleviate both problems, scientists are working on topical compounds that would restore fat levels and possibly increase the expression of Ctip2, said Arup Indra, an associate professor in the OSU College of Pharmacy. The development of such treatments could eventually lead to personalized gene therapies, says Indra. “Our understanding of genomics is improving day by day, even hourly,” Indra says. “The challenge is using that understanding to develop therapies that are effective.”

 

More Articles

Startup or Grow Up?

September 2014
Tuesday, August 26, 2014
BY JON BELL

Startup culture is all the rage. Is there a downside?


Read more...

The Alchemist

September 2014
Tuesday, August 26, 2014
BY LINDA BAKER

David Howitt explains why Portland consumer brands like Stumptown and Voodoo Doughnuts are taking the world by storm.


Read more...

Shipping News

September 2014
Tuesday, August 26, 2014
BY JENNIFER MARGULIS

In 2012 The Dalles, a city of some 14,400 located 75 miles east of Portland and often seen as the poor cousin to adjacent Hood River, completed a massive project to revitalize its dock.


Read more...

Powerlist: Colleges and Universities

September 2014
Wednesday, August 27, 2014
BY KIM MOORE

A conversation about higher education with the presidents of the University of Oregon and Clackamas Community College, followed by September's powerlist.


Read more...

Two Sides of the Coin

Contributed Blogs
Friday, September 26, 2014
0926 iphone6-thumbBY JASON NORRIS | GUEST BLOGGER

This post focuses on the recent release of the new Apple iPhone as well as Alibaba's IPO, the largest U.S. IPO in history.


Read more...

November/December Preview: Revenge Forestry

News
Tuesday, October 14, 2014
BY JONATHAN FROCHTZWAJG

Seneca AW46A flare-up in the Elliott Forest raises questions about détente in Oregon’s timber wars.


Read more...

Fast Food Slows Down

September 2014
Tuesday, August 26, 2014
BY KIM MOORE

The ubiquitous fast-food restaurant may be on the decline.


Read more...
Oregon Business magazinetitle-sponsored-links-02
SPONSORED LINKS